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Year Number of Results
1990 1
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2002 7
2003 6
2004 2
2005 5
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2007 5
2008 5
2009 4
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113 results

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Page 1
Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.
Van Damme H, Dombrecht B, Kiss M, Roose H, Allen E, Van Overmeire E, Kancheva D, Martens L, Murgaski A, Bardet PMR, Blancke G, Jans M, Bolli E, Martins MS, Elkrim Y, Dooley J, Boon L, Schwarze JK, Tacke F, Movahedi K, Vandamme N, Neyns B, Ocak S, Scheyltjens I, Vereecke L, Nana FA, Merchiers P, Laoui D, Van Ginderachter JA. Van Damme H, et al. J Immunother Cancer. 2021 Feb;9(2):e001749. doi: 10.1136/jitc-2020-001749. J Immunother Cancer. 2021. PMID: 33589525 Free PMC article.
These findings were validated by flow cytometric analysis of both mouse (LLC-OVA, MC38 and B16-OVA) and human (NSCLC and melanoma) tumor samples. We generated two CCR8-specific nanobodies (Nbs) that recognize distinct epitopes on the CCR8 extracellular domain. ...RE …
These findings were validated by flow cytometric analysis of both mouse (LLC-OVA, MC38 and B16-OVA) and human (NSCLC and melanoma) tumor sam …
Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.
Dangi A, Husain I, Jordan CZ, Yu S, Natesh N, Shen X, Kwun J, Luo X. Dangi A, et al. J Am Soc Nephrol. 2022 Oct;33(10):1876-1890. doi: 10.1681/ASN.2022020139. Epub 2022 Aug 16. J Am Soc Nephrol. 2022. PMID: 35973731 Free PMC article.
BACKGROUND: In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions. ...CONCLUSIONS: Target …
BACKGROUND: In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators …
The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis.
Liu SS, Liu C, Lv XX, Cui B, Yan J, Li YX, Li K, Hua F, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Li PP, Zhou ZG, Xiao Y, Hu ZW. Liu SS, et al. Immunity. 2021 Sep 14;54(9):2042-2056.e8. doi: 10.1016/j.immuni.2021.06.008. Epub 2021 Aug 17. Immunity. 2021. PMID: 34407391 Free article.
Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important in the pathology of inflammatory diseases. ...Immunofluorescence analyses revealed that alveolar macrophages and CD4(+) T cells were major producers of CCL1 and targeted deletion of …
Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important in the pathology of inflammatory diseases. …
Cytokines and chemoattractants in allergic inflammation.
Romagnani S. Romagnani S. Mol Immunol. 2002 May;38(12-13):881-5. doi: 10.1016/s0161-5890(02)00013-5. Mol Immunol. 2002. PMID: 12009564 Review.
Moreover, both Th2 cells and the effector cells usually present in the areas of allergic inflammation (basophils, mast cells, and eosinophils) express chemoattractant receptors, such as CCR3, CCR4, CCR8 and CRTH2. Therefore, interactions of eotaxin(s), eotaxin/CCL11 …
Moreover, both Th2 cells and the effector cells usually present in the areas of allergic inflammation (basophils, mast cells, and eos …
Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.
Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD. Mikhak Z, et al. J Allergy Clin Immunol. 2009 Jan;123(1):67-73.e3. doi: 10.1016/j.jaci.2008.09.049. Epub 2008 Dec 4. J Allergy Clin Immunol. 2009. PMID: 19062085 Free PMC article.
BACKGROUND: Recruitment of antigen-specific T(H)2 cells into the lung is critical for the development of allergic airway inflammation. Although CCR4 and CCR8 are preferentially expressed on T(H)2 cells and CCR4, CCR8, and CXCR3 ligands are increased in asthma …
BACKGROUND: Recruitment of antigen-specific T(H)2 cells into the lung is critical for the development of allergic airway inflammation …
Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis.
Honda F, Tsuboi H, Ono Y, Abe S, Takahashi H, Ito K, Yamada K, Kawano M, Kondo Y, Asano K, Tanaka M, Malissen M, Malissen B, Matsumoto I, Sumida T. Honda F, et al. Arthritis Res Ther. 2021 Aug 14;23(1):214. doi: 10.1186/s13075-021-02597-6. Arthritis Res Ther. 2021. PMID: 34391459 Free PMC article.
BACKGROUND: Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggesting that the CCL18-CCR8 axis is implicated in the etiology of IgG4-RD, although whether this axis has a potential …
BACKGROUND: Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related diseas …
CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.
Gombert M, Dieu-Nosjean MC, Winterberg F, Bünemann E, Kubitza RC, Da Cunha L, Haahtela A, Lehtimäki S, Müller A, Rieker J, Meller S, Pivarcsi A, Koreck A, Fridman WH, Zentgraf HW, Pavenstädt H, Amara A, Caux C, Kemeny L, Alenius H, Lauerma A, Ruzicka T, Zlotnik A, Homey B. Gombert M, et al. J Immunol. 2005 Apr 15;174(8):5082-91. doi: 10.4049/jimmunol.174.8.5082. J Immunol. 2005. PMID: 15814739
Although DC maintain their CCR8+ status during maturation, brief activation of circulating T cells recruits CCR8 from intracytoplamic stores to the cell surface. Moreover, the inflammatory and atopy-associated chemokine CCL1 synergizes with the homeostatic chemokine …
Although DC maintain their CCR8+ status during maturation, brief activation of circulating T cells recruits CCR8 from intracyt …
Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.
Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez-A C, Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJ. Gonzalo JA, et al. J Immunol. 2007 Aug 1;179(3):1740-50. doi: 10.4049/jimmunol.179.3.1740. J Immunol. 2007. PMID: 17641040
In vivo, CCL1 expression in the lung is reduced in mast cell-deficient mice after aeroallergen provocation. Neutralization of CCL1 or CCR8 deficiency results in reduced mucosal lung inflammation, airway hyperresponsiveness, and mucus hypersecretion to a similar degr …
In vivo, CCL1 expression in the lung is reduced in mast cell-deficient mice after aeroallergen provocation. Neutralization of CCL1 or CCR …
Inflammatory chemokine (C-C motif) ligand 8 inhibition ameliorates peritoneal fibrosis.
Lee Y, Lee J, Park M, Seo A, Kim KH, Kim S, Kang M, Kang E, Yoo KD, Lee S, Kim DK, Oh KH, Kim YS, Joo KW, Yang SH. Lee Y, et al. FASEB J. 2023 Jan;37(1):e22632. doi: 10.1096/fj.202200784R. FASEB J. 2023. PMID: 36468785
Immunohistochemical analysis revealed that CCL8 along with fibrosis- and inflammation-related markers were significantly increased in the PF mouse model. Functional blockade of CCL8 using a CCR8 inhibitor (R243) abrogated peritoneal inflammation and fibrosis …
Immunohistochemical analysis revealed that CCL8 along with fibrosis- and inflammation-related markers were significantly increased in …
A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation.
Knipfer L, Schulz-Kuhnt A, Kindermann M, Greif V, Symowski C, Voehringer D, Neurath MF, Atreya I, Wirtz S. Knipfer L, et al. J Exp Med. 2019 Dec 2;216(12):2763-2777. doi: 10.1084/jem.20182111. Epub 2019 Sep 19. J Exp Med. 2019. PMID: 31537642 Free PMC article.
Although their physiological and detrimental immune functions seem to depend on the anatomical compartment they reside, their tissue tropism and the molecular and immunological processes regulating the self-renewal of the local pool of ILC2s in the context of inflammation …
Although their physiological and detrimental immune functions seem to depend on the anatomical compartment they reside, their tissue tropism …
113 results